Cefixime is used in acute and chronic bacterial infections with cefiximesensitive bacteria such as streptococci. Drugs az pill identifier supplements symptom checker. Cefixime is an oral third generation cephalosporin, frequently used in respiratory. In an open trial children with suspected typhoid fever were randomized to receive either ofloxacin 10 mgkgday in two divided doses. Cefixime ofloxacin tablet may also be used for purposes not listed in this medication guide. Furthermore, these are infections of the ear, nose and throat, such as middle ear infections runny nose and sinusitis tonsillitis strep throat. Availability of cefixime 400 mg tablets united states. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of. Cefixime medical definition merriamwebster medical. An openlabeled, noncomparative, study was conducted in 112 subjects to evaluate the efficacy and safety of cefixime 5mgkg or 200mg twice daily for 7 days for the treatment of typhoid fever. Yes, typhoid fever and bacterial infections are among the most common reported uses for cefixime ofloxacin tablet.
Cefixime is used to treat certain infections caused by bacteria such as bronchitis infection of the airway tubes leading to the lungs. Admet data is predicted using admetsar, a free tool for evaluating. See what others have said about cefixime, including the effectiveness, ease of use and side effects. Webmd provides common contraindications for cefixime oral. Suprax cefixime for gonococcal infection, uncomplicated. Cefixime may also be used for purposes not listed in this medication guide. Tell your doctor about the allergy and what signs you had.
This medication is known as a cephalosporin antibiotic. Killed the damn clap on the first try with just 1 dose in conjunction with the heavy dose of azithromycin also had a really bad case of strep throat that wasnt cured with penicillin v. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Within this class, ceftriaxone, available only as an injection, is the recommended treatment for all types of gonorrhea infections i. Pdr drug summaries are concise pointofcare prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their practice pdr s drug summaries are available free of charge and serve as a great resource for us based mds, dos, nps and pas in patient practice. Jan 01, 2020 cefixime chewable tablets are bioequivalent to oral suspension. Suprax cefixime is an antibiotic prescribed for the treatment of bacterial infections such as sore throat, ear infection, tonsillitis, laryngitis, pneumonia, bronchitis, uti, copd, and gonorrhea. A multinational, worldwide study has confirmed the. Drugs az pill identifier supplements symptom checker diseases dictionary media.
Overview of cefixime use in communityacquired infections clinical. Cefixime is used to treat many different types of infections caused by bacteria. Suprax cefixime side effects, images, uses, dosage. These highlights do not include all the information needed to use cefixime for oral suspension safely and effectively. Minor in vitro, salicylates have displaced cefixime from its proteinbinding sites, resulting in a 50% increase in free cefixime levels. Oral alternatives to cefixime for the treatment of uncomplicated neisseria gonorrhoeae urogenital infections. The water molecules in the crystal lattice are considered to play a significant role in the chemical stability of cefixime, as the dihydrate and anhydrate forms have been. Suprax cefixime antibiotic side effects, dosage, uses. Find out what health conditions may be a health risk when taken with cefixime oral. Find patient medical information for cefixime oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. In canada, due to increased antimicrobial resistance, the public.
It is reported to be much more active in vitro than cefixime against staphylococcus aureus and enterococcus faecalis, but it is less active against enterobacteriaceae. What do i need to tell my doctor before i take cefixime capsules and tablets. Introduction cefixime was quickly established in the western countries as a potent broadspectrum antibiotic with a variety of indications. The method aims at the prior amino deprotection to make an improvement, and uses penicillin acylase to substitute trifluoroacetic acid and so on in the. A comparative study of ofloxacin and cefixime for treatment.
In general the halflife of the drug is about 3 to 4 hours and is not dependent on dose. Cefixime is a broadspectrum antibiotic used to treat a variety of conditions like urinary tract infections, ear infections and lung infections caused by bacteria. The pharmacokinetics of the extendedhalflife, broadspectrum oral cephalosporin cefixime cl 284,635. Please do not use cefixime ofloxacin tablet for typhoid fever and bacterial infections without consulting first with your doctor. An openlabel, singledose, randomized, 2way crossover study was conducted in. Learn about drug imprint, side effects, uses treating, dosage, interaction, overdose, and warnings. This includes otitis media, strep throat, pneumonia, urinary tract infections, gonorrhea, and lyme disease. To reduce the development of drugresistant bacteria and maintain the effectiveness of suprax cefixime and other antibacterial drugs, suprax should be used only to treat or prevent. Consumer information about the medication cefixime oral suprax, includes side effects, drug interactions, recommended dosages, and storage information. Cefixime side effects, uses, dosage, overdose, pregnancy. See full prescribing information for cefixime for oral suspension. Pdf typhoid fever is defined by fever greater then 38. Suprax cefixime is indicated in the treatment of the following infections caused by susceptible strains of the. As does penicillin, the betalactam antibiotic cefixime inhibits bacterial cell wall synthesis by disrupting peptidoglycan synthesis, resulting in a reduction in bacterial cell wall stability and bacterial cell lysis.
Availability of cefixime had been limited since july 2002, when wyeth pharmaceuticals collegeville, pennsylvania discontinued manufacturing cefixime tablets in the united states. Cefixime fda prescribing information, side effects and uses. Cefixime is used to treat a wide variety of bacterial infections. Dec 25, 2019 cefixime is an antibiotic useful to treat a number of bacterial infections. Apr 30, 2004 ceftibuten 400 mg is not as active as cefixime in vitro, and has been evaluated in only one clinical trial limited to men with uncomplicated urethritis. Sideeffects were transient and disappeared after finishing therapy in all three of the cases.
Fk 027 in healthy subjects and patients with renal insufficiency. Cefixime is a prescription medication used to treat bacterial infections of the lungs, urinary tract, ears, throat, and infections that cause gonorrhea. In the united states it is a second line treatment to ceftriaxone. A broadspectrum, thirdgeneration cephalosporin antibiotic derived semisynthetically from the marine fungus cephalosporium acremonium with antibacterial activity. It is given by mouth in a usual dose of 600 mg daily as a single dose. Cefixime ofloxacin tablet is used for typhoid fever, bacterial infections, urinary tract infections, eye and ear infection, skin infections, respiratory infections, typhoid, bacterial infection, infections of the skin, sexually transmitted infections and other conditions. Cefixime, an orally active thirdgeneration cephalosporin, has attracted considerable attention following the results of numerous clinical studies. Up to the oral dose of 3200 mgkg in rats, cefixime. Similar to that of secondgeneration cephalosporins, but activity against staphylococci is less, while activity against gramnegative pathogens is greater, even for organisms resistant to first and secondgeneration agents.
The water molecules in the crystal lattice are considered to play a significant role in the chemical stability of cefixime, as the dihydrate and anhydrate forms have been found to be less stable than is the trihydrate form 18. Apr 24, 2008 the only oral agent recommended currently by cdc for treatment of uncomplicated urogenital or rectal gonorrhea is a single dose of cefixime 400 mg. Cefixime, an orally administered third generation cephalosporin, was compared with ofloxacin for the treatment of uncomplicated typhoid fever in children. An overview of uses for cefixime cefixime suprax is a prescription antibiotic licensed to treat a variety of different infections. It will not work for viral infections such as common cold, flu. Cefixime is in a class of medications called cephalosporin antibiotics. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of betalactamases, may be susceptible to cefixime. Cefixime is a cephalosporin sef a low spor in antibiotic. Binds to the bacterial cell wall membrane, causing cell death. Shv1 ensures that its antibacterial activity is free. Cefixime tablet is used for an uncomplicated urinary tract infection, an uncomplicated sexually transmitted infection affecting the urethra and rectum gonorrhea, middle ear infection otitis media, an unstable lung function due to worsening of the airflow pathway acute exacerbations of longterm bronchitis, or throat infection pharyngitis and tonsillitis. This may be given as a 400 mg tablet or capsule daily or the 400 mg tablet may be split and given as one half tablet every 12 hours. Respiratory infections the bacterial species most commonly implicated in communityacquired respiratory tract infections are streptococcus pneumoniae. Cefixime tablet is used to treat certain bacterial infections including urinary tract infections, ear infections, throat infections including pharyngitis and tonsillitis, and sexually transmitted infections, such as, gonorrhea, that are affecting the urethra and rectum.
In the united states it is a second line treatment to ceftriaxone for gonorrhea. Cefixime is contraindicated in patients with known sensitivity or allergies to cephalosporin class of antibiotics. D r guay, r c meatherall, g k harding, and g r brown. Availability of cefixime 400 mg tablets united states, april 2008 the only current cdcrecommended options for treating neisseria gonorrhoeae infections are from a single class of antibiotics, the cephalosporins. For use in the treatment of the following infections when caused by. Do not use aurocefixime tablets to treat staphylococcus aureus as this strain of staphylococcus is. Keeping in view the efficacy, safety and ease of administration, cefixime could be included in the list for the treatment of uncomplicated anogential gonorrhea. Cefixime crystallizes with three waters of hydration, which is the most stable crystalline form. If you are allergic to this medicine cefixime capsules and tablets.
Cefixime is highly stable in the presence of betalactamase enzymes. The pharmacokinetics of cefixime were determined in adult and pediatric subjects. Cefixime, an antibiotic, is a thirdgeneration cephalosporin like ceftriaxone and. Was switched to cefixime for this and it worked like a charm in less than 24 hours. Suprax cefixime dose, indications, adverse effects.
Comparative studies between cefixime and conventional antibiotics for the treatment of upper respiratory tract infections and otitis media are summarized. Inclusion of cefixime in who model list of essential. Read more about the prescription drug cefixime oral. It is used to treat certain kinds of bacterial infections. As family practitioners working in community health centers, we were dismayed to receive a letter march 1, 1990 informing us of the national association of community health centers involvement with the suprax family health fund. The clinical significance of this effect is unclear at this time. The invention provides a method for preparing cefixime, which belongs to the medicine synthesis technical field and comprises the steps of preparation of 7avca, preparation of cefixime methyl ester, preparation of the cefixime and so on. Free cefixime in community health centers jama jama. For more recent treatment information, see the std treatment guidelines.
Data sources include ibm watson micromedex updated 28 feb 2020, cerner multum updated 2 mar 2020, wolters kluwer updated. Cefixime tablets and suspension, given orally, are about 40% to 50% absorbed whether administered with or without food. Jul 18, 20 cefixime is a prescription medication used to treat bacterial infections of the lungs, urinary tract, ears, throat, and infections that cause gonorrhea. When cefixime tablets was used as single 400 mg dose therapy in clinical trials in the treatment. Cefixime 400 mg orally in a single dose, or ceftriaxone 125 mg im in a single dose. Cefixime oral suprax side effects, medical uses, and drug. Some of the information in these alternatives is out of date.
Nov 09, 2018 cefixime is a cephalosporin sef a low spor in antibiotic. Cefdinir is a thirdgeneration oral cephalosporin antibiotic similar to cefixime. The online clinic no longer prescribes cefixime, but we may be able to prescribe an alternative for you depending on the infection you are seeking to treat. For the treatment of uncomplicated cervicalurethral gonococcal infections, a single oral dose of 400 mg is recommended. Cefixime is licensed for adults and children who have infections caused by certain types of bacteria.
Cefixime is also used to treat worsening symptoms of severe cases of bronchitis. Fk 027 were studied in 7 healthy volunteers and 35 patients with various degrees of renal insufficiency, including patients undergoing continuous. Cefixime in 400 mg dose has been included as one of the first line drugs in cdc, who and european guidelines for treatment of uncomplicated gonococcal anogenital infection. Cefixime jordan university of science and technology. This emedtv web page focuses on specific uses for cefixime, including approved and unapproved uses. Dec 04, 2019 cefixime chewable tablets are bioequivalent to oral suspension. Topics az slideshows images quizzes supplements medications. Pharmacokinetics and bioequivalence study of two formulations of cefixime in healthy male volunteers hossein danafar a,b, mehrdad hamidic azanjan pharmaceutical nanotechnology research center, zanjan university of medical sciences, zanjan, iran. Pdf clinical role of cefixime in communityacquired infections.
Cefixime was formerly prescribed to treat patients with gonorrhoea, but this is no longer recommended. This medicine is not recommended for use in case of common cold, flu or viral infections since it is active against the infections caused by certain bacterial species only. Cefixime belongs to a group of drugs called cephalosporin antibiotics, which work to stop the growth of bacteria in the body. Treatment of uncomplicated urinary tract infections due to escherichia coli and proteus mirabilis, otitis media due to. Get a printable copy pdf file of the complete article 939k, or click on a page image below to browse page by page. When and why find, read and cite all the research you need on researchgate. Pdf on jul 1, 1995, ben jk tan and others published cefixime use in children. Cefixime, an antibiotic, is a thirdgeneration cephalosporin like ceftriaxone and cefotaxime.
Drug information on suprax cefixime includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. Archived from the original pdf on 23 february 2015. The oral suspension produces average peak concentrations. Cefixime in the treatment of upper respiratory tract.